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- Sonic SatAM Liberations PSP
- Sonic Screwdriver
- Sonic The Game
- Sonic The Hedgehog Run Vita
- Sonic Time Twisted Switch
- Sonic Time Twisted Vita
- Sonic Unleashed Vita
- Sonic Vita
- Sonic Vitality Vita
- Sonic the Hedgehog
- Sony Homebrew Manager Vita
- Sony Infrared Keyboard Reader GB
- Sonyc GBA
- Sonymon PSP
- Soon Soon
- Soon Soon1
- Soon Soon 2
- Soon Soon 21
- Sopwith
- Sopwith PSP
- Sora no Woto - Otome no Gojuusou Translation PSP
- Sorcerer of Claymorgue Castle
- Sorcery GBA
- Sorcery of the Sea GB
- SotoProject
- SoulCalibur Vita
- Soul Eater - Battle Resonance PSP
- Soul Eater - Medusa no Inbou
- Soul Eater - Monotone Princess English Translation Wii
- Soul Eater - Training for a Meister PSP
- Soul Sacrifice Delta Trainer Vita
- Soulless PSP
- SounDS
- SoundBoardDS
- SoundEffects PSP
- Sound Cells
- Sound Demo GB
- Sound Mixer GBA
- Sound Orbit
- Sound Way
- Soundhax 3DS
- Soup Raiders - Jailbreak GB
- South Africa World Cup 2010 DS Manager
- South Park SMM Mod PSP
- South Park Sound
- South Pong GB
- Southern Dreams - SMART Demo GB
- Southern Dreams - Slideshow GB
- Soviet Snake GB
- Space1
- SpaceARMy GBA
- SpaceBubble Wii
- SpaceHulk-PSP
- SpaceShip Omega Wii
- Space Assault PSP
- Space Ball for PSP
- Space Bridge PSP
- Space Cadet Pinball NX Switch
- Space Cadet Pinball Vita
- Space Cadet Pinball Wii U
- Space Cobra RetPixMod PSP
- Space Combat PSP
- Space Commander Pac Man GBA
- Space Crawler GB
- Space Debri GB
- Space Demo GB
- Space Duel GB
- Space Escape PSP
- Space Evader PSP
- Space Faces GB
- Space Flight PSP
- Space For Everything PSP
- Space Fruit 3DS
- Space GB
- Space Game GBA
- Space Game NX Switch
- Space Game Wii U
- Space Impakto DS
- Space Invaders 2600 GBA
- Space Invaders 2600 PSP
- Space Invaders Arcade Emulator Wii
- Space Invaders Clone GB
- Space Invaders DS
- Space Invaders GB
- Space Invaders GBA
- Space Invaders Portable PSP
- Space Invasion GB
- Space Invasion Zero GB
- Space Loonies GBA
- Space Math DS
- Space Mission DX GB
- Space Pilot
- Space Pong
- Space QIX GBA
- Space Rocks GBA
- Space Runner GBA
- Space Shooter GBA
- Space Shooter Vita
- Space Shooter Wii
- Space Sound GB
- Space Tapper GBA
- Space Times GBA
- Space Twins GBA
- Space Waste GB
- Space splosionator 2086 GB
- Spacecraft-NX Switch
- Spacecraft PSP
- Spaceinvaders 3DS
- Spacelua PSP
- Spacewar GB
- Spacewars PSP
- Spacial Warfare PSP
- Spank The Monkey DS
- Spd Loader Wii
- Spearmint Mountain Switch
- SpeccyDS
- SpecializeMii "Plus" 3DS
- SpecializeMii 3DS
- Spectre3ds
- SpectrumDS
- SpeedX3D 3DS
- Speed DS
- Speed Puzzle PSP
- Speed Trap
- Speed for GBA
- Speed tester for libfat
- Speeder PSP
- Speedfinger GB
- Speedrun Vita
- Speedy Gonzales Aztec Adventure 5 GB
- Spelling Bubbles
- SpelunkyDS
- Spelunky Classic HD Vita
- Spelunky PSP
- Sphere DS
- Spherical Harmonics Demo PSP
- SpiceBoy PSP
- Spice and Wolf - My Year with Holo English Patch
- Spice and Wolf - The Wind that Spans the Sea English Translation
- Spiced Miku Vu Vita
- Spider-Man - Homecoming GBA
- Spider3DSTools 3DS
- SpiderVita
- Spider DS
- Spider Solitaire DS
- Spider Solitaire PSP
- Spiik Wii U
- Spike
- Spike Dislike DS
- Spike Dislike GB
- Spiky Harold 3DS
- Spinal Media Player
- Spinning Ame GBA
- Spinstar Vita
- Spinvader GBA
- Spiral - Game Boy Music ROM GB
- Spirited DS by KahnerC
- Spirits DS
- Spirits Wii
- Spirograph PSP
- Splash-ds 3DS
- Splash04 GB
- SplashMakerSwitch
- Splash Screen Example GBA
- Splat GBA
- Splatter Castle Wii
- SplitNSP-Swift-GUI Switch
- SplitNSPSharp Switch
- SplitNSP Switch
- Split XCI Switch
- Splitted in the Midst GB
- Spong GB
- Spoofer PSP
- Spoofix PSP
- Spooky Maze PSP
- Spooky Mission 2 - The Nightmare Before Christmas GBA
- Spoon's ASCII Mess
- Spout
- SpoutDS
- SpoutEX
- SpoutGBA
- Spout PSP
- Spring Physics DS
- Sprite Combat
- Sprite Maker XP PSP
- Sprite Overlapping GB
- SpritesOut
- Sproing GBA
- Sprouty's Quest Vita
- SpsychoD
- Spy Calculator PSP
- Spy Farmer GB
- Spyro Advance GBA
- Sqrxz 2 3DS
- Sqrxz 2 Wii
- Sqrxz 3 3DS
- Sqrxz 3 Vita
- Sqrxz 3 Wii
- Sqrxz 4 3DS
- Sqrxz 4 Vita
- Sqrxz 4 Wii
- Sqrxz GB
- Sqrxz Wii
- SquarO
- SquarO PSP
- SquareAtrap PSP
- SquareBounce
- SquareDS
- SquareForce PSP
- Square Fall GB
- Square GB
- Square Invaders PSP
- Squarez PSP
- Squash DS
- Squashly Boop 3DS
- Squeek GBA
- Squid Game Vita
- Squirm
- Squishy Bird DS
- Squishy the Turtle GB
- Ssbu-Arc-Extract Switch
- Sssss PSP
- StackMill 3DS
- Stacker
- Stacker PSP
- Stacker for Vita
- Stadin Brankkari GB
- Stage Puncher Switch
- Stakker PSP
- Stalker GB
- Standby Shotcut Vita
- StarCraft for Nintendo 3DS
- StarGun for PSP
- StarKiller 2D Vita
- StarLite DS
- StarPiece GB
- StarPlot Wii
- StarUpdater-UN 3DS
- StarUpdater 3DS
- Star Control Spaceship Combat GB
- Star Cruiser 7 3DS
- Star Fighter GB
- Star Fortress Dendron GBA
- Star Fox 64 3D Mod
- Star Heritage GB
- Star Ocean: The Second Story R SaveDate Editor Switch
- Star Ocean - First Departure Difficulties PSP
- Star Shooter GBA
- Star Shot GBA
- Star Tex GB
- Star War Battles
- Star Wars: Die Solo
- Star Wars Xbox
- Starcatcher Vita
- Stardew Valley Champloo Anime Mod Vita
- Stardull
- Stardust Engine PSP
- Starfall DS
- Starfall Wii
- Starfield Vita
- Starfield Wii
- Starfight GB
- StarfighterX Xbox
- Starfighter Skirmish
- Starfisher GB
- Stargrazer
- Staris
- StarquakeDS
- StartPatch Mod Wii
- StartPatch Wii
- Stasis GB
- Status Monitor Overlay Switch
- Staybright Vita
- Staydown GB
- SteadyHand Wii
- Steam
- Steam InHome Streaming Switch
- Steam Ponk
- StefaN GB
- Steins;Gate: My Darling's Embrace PSP - English Translation
- Steins;Gate PSP - English Translation
- SteinsGate 0 Translation Improvement Patch Vita
- SteinsGate 8-bit GB
- SteinsGate Divergence PSP
- SteinsGate Elite PSVita English Translation Patch Vita
- SteinsGate Linear Bound Phenogram English Port Vita
- SteinsGate My Darlings Embrace English Patch Vita
- StellaDS
- StellaDS - PHOENIX EDITION
- StellaDS Phoenix Edition
- StellaPSP
- StellaWii
- Stella Wars 3DS
- StemLoader Vita
- StepMania Switch
- Stepmaniax Xbox
- Stercus Accidit PSP
- Stercus Accidit Wii
- Stereotype Volleyball PSP
- Sterus GBA
- StickGBC
- Stick Kicker GBA
- StickmanJump PSP
- Stickman DS
- Sticky Hooves In The Temple Of Vel-Cro GB
- StillAliveDS
- StillAliveWii
- StillGots PSP
- Stitchd PSP
- Stock App Remover Vita
- Stockmarket DS
- Stomp The Slime GB
- Stomper Vita
- Stone Age
- Stone Age DS
- Stone Constructor GB
- StopWatch by Ken GB
- Stop at 1000 PSP
- Stop at 500
- Stoppuhr DS
- StopwatchDS
- Stopwatch DS
- Stopwatch PSP
- Stopwatch Wii
- Stopwatch by Chris GB
- StorageFormat Vita
- StorageMgr Vita
- Storm GBA
- Storm Lover Ka Translation Patch PSP
- Storm The House
- Story Of Season - Pioneers of Olive Town Translation Switch
- Story of Seasons - Trio of Towns - Hamtaro and Cheburashka Restoration Patch 3DS
- Story of Seasons - Trio of Towns - True Love Edition 3DS
- Story of Seasons Friends of Mineral Town English Switch
- Story of Seasons Save Editor 3DS
- Story of Seasons Save Editor EUR 3DS
- Str2hax Wii
- Stratagem Hero Vita
- Stratagus-vita
- Strato-Naut PSP
- Stray Cat DS
- Streamer-ds
- Street Fighter DS
- Street Racing Vita
- Streetpass Mii Plaza Puzzle Swap Save Editor 3DS